The hotel is easily reached from the airport via the excellent Berlin train system. The Friedrichstrat train station is only a 5 min walk to the hotel, so I would recommend the train w/o hesitation. The hotel is in a great location, especially for eating and drinking. The hotel and train station are right beside the Spree river which runs through parts of Berlin. There are several riverside restaurants within walking distance of the hotel, several with seating right along the river across the street from the main restaurant. There are ATM's nearby, Freidrichstadt Place performing arts theatre plus shopping on Freidrichstadt street as well(except Sunday) The Brandenburg Gate is within walking distance, along with Checkpoint Charlie and other Berlin wall museums, etc.
The hotels location may be better than the actual hotel. We stayed in a double room which was very small. There are 2 beds, but they are pushed together with very little room to push them apart for some personal space. the room has a shower, room with a toilet and tiny sink, small desk and chair and that's about it. It is probably the smallest hotel room I have ever stayed in, with no room to spare. The beds are very small and you can literally reach out and touch the person next to you. The AC was also inadequate during our stay when the temperature in Berlin was 25-30(75-85) We stayed 2 separate times over a 10 day stay in different rooms and both times the room was hot making sleeping uncomfortable. The hotel offers breakfast for 12 Euros or so which we did not try due to the large # of choices nearby which seemed to be more economical and interesting. The nearby train station also offered fast food choices such as Macdonalds, Dunkin Donuts & small grocery store.
In conclusion, the hotel is modern & adequate, but with very small rooms. If you are large people, I can guarantee you will not be happy with a "double" room, as you will be breathing down each others throat when sleeping. Maybe a room for 4 would be much larger, but I cannot speak about that. The location is great for eating & drinking along the river and as a base for further travel around Berlin using the nearby Friedrichstrat train station. We would use again mostly because of the location but have seen enough of Berlin. less