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Best Western Plus Sikeston

AAA - 2 Diamond

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Sikeston hotels are convenient and make traveling easy, and this popular favorite is located close to Interstate 55 and 57.

Your Best Western Plus Sikeston is pet-friendly, welcoming the entire family whether its for a vacation or business trip. Hotels in Sikeston are renowned for hospitality, but the bar is set high at this property. Near the Sikeston Rodeo, there are endless entertainment options that draw travelers from around the country. Business travelers and leisure travelers alike enjoy the homey amenities and great customer service.

Looking for the best Sikeston, MO hotels? Our property is affordable and boasts the absolute best service in town. A popular stopping point for travelers, make sure to visit some local favorites like Lamberts Caf, just a few minutes away from this Sikeston hotel. The Azalea Festival is a favorite local event, and theres always something special happening nearby. Ask a friendly staff member for recommendations or an insiders tip on must-see destinations.

Business travelers with Tyson Foods, Unilever and Noranda Aluminum depend on our Sikeston hotel for extended stays. Offering corporate travelers and government employees, such as those with BNSF, the best rates in town guarantees a stress-free trip. Newly renovated and just 20 miles to the Mississippi River, you deserve only the best Sikeston hotel on your next trip. Plus, staying 30 miles to the nearest casino means the best in gaming and entertainment is a short commute away.

Reserve your next stay at Best Western Plus Sikeston where the comfort of guests is a top priority! Enjoy your stay.

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120 S Interstate Drive
United States
AAA - 2 Diamond


Pets: No Pets accepted
Check-in & Check-out
15:00:00 | 11:00:00


Location and Attractions

Getting there.

Sat nav users: type 63801-8641

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120 S Interstate Drive
United States

What's nearby?


  • 13.00 mile(s) from Charleston

  • 53.00 mile(s) from Poplar Bluff

  • 55.00 mile(s) from Caruthersville

  • 60.00 mile(s) from Paducah, Kentucky

  • 60.00 mile(s) from Perryville

  • 65.00 mile(s) from Blytheville, Arkansas

  • 70.00 mile(s) from Metropolis, Illinois

  • 140 mile(s) from St. Louis

  • 150 mile(s) from Memphis, Tennessee

  • 13.00 mile(s) from Benton

  • 265 mile(s) from Branson

  • 20.00 mile(s) from New Madrid

  • 20.00 mile(s) from Dexter

  • 30.00 mile(s) from Cape Girardeau

  • 40.00 mile(s) from Jackson

  • 0.05 mile(s) from Steward Steel, 101 N. Interstate Drive, Sikeston, MO. 573-471-2121

  • 0.05 mile(s) from FedEx® Shipping Center, 2830 E Malone, Sikeston, MO.

  • 2.00 mile(s) from Tetra Pak®, 2200 E. Malone Avenue, Sikeston, MO. 573-471-1441

  • 4.00 mile(s) from Unilever® South Plant, 1000 County Line Road Sikeston, MO. 573-471-7051

  • 5.00 mile(s) from Cott Beverage, 301 Larcel Drive, Sikeston, MO 573-471-4445

  • 6.00 mile(s) from Atlas Cold Storage, 2500 Rose Parkway, Sikeston, MO 573-471-7727

  • 6.00 mile(s) from Americold® Logistics, 2500 Rose Parkway, Sikeston, MO. 573-471-7727

  • 6.00 mile(s) from Missouri Department of Transportation (MoDOT), 2675 N. Main Street, Sikeston, MO. 573-472-5333

  • 6.00 mile(s) from Do it Best, 2600 Rose Parkway, Sikeston, MO. 573-472-5770

  • 6.00 mile(s) from Unilever® North Plant, 2400 Rose Parkway, Sikeston, MO.

  • 6.00 mile(s) from Cargill®, 410 W. Malone Avenue, Sikeston, MO. 573-472-2272

  • 7.00 mile(s) from Orgill, 2727 N. Main Street, Sikeston, MO. 573-471-2071

  • 8.00 mile(s) from Alan Wire, 814 S. West Street, Sikeston, MO. 573-471-9548

  • 20.00 mile(s) from Tyson® Foods, 1001 E. Stoddard Street, Dexter, MO.

  • 26.00 mile(s) from Noranda® Aluminum, 391 Saint Jude Industrial Park, Marston, MO. 573-643-2361

  • 3 mile(s) from Three Rivers Community College

  • 8 mile(s) from Southeast Missouri State, four year university

Room Theatre Classroom U-Shape Boardroom Banquet
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TripAdvisor Traveller Rating: Rating: Based on 326 traveller reviews
Rating: 5 185
Rating: 4 97
Rating: 3 21
Rating: 2 15
Rating: 1 8

Best Western Sikeston MO

28/01/2018 Y8818HOjeanp, Adel, Iowa

We have stayed here several times and have always had a great experience. Friendly people, clean facility and quiet surroundings. Convenient to get to and great dining available a short distance from ... more

Owner Response
Anita J, General Manager at Best Western Plus Sikeston, responded to this review
Hello, We all appreciate the great review and rating. We love to hear when a guest enjoys staying with us! Thank you for your business and come see us again!

Over priced

27/01/2018 hardyo2017, Richardson

I've stayed in a lot of hotels some good and some really crappy ones, this one cost $100.00 plus tax during the middle of the week. I've stayed in some very nice beatwestern plus's for 30.00 less and ... more

Owner Response
Anita J, General Manager at Best Western Plus Sikeston, responded to this review
Valued Guest, I apologize that you felt that we were overpriced. We have great rooms and a awesome breakfast each morning, Our breakfast consist of biscuits and gravy, sausage, eggs, bacon, waffles with all the fixings. We also are located right off of I 55 which is very convenient. We do appreciate your business and if ever in the area come on back and stay with us!

Great rooms and great service reasonalble price

21/01/2018 retiredfire, Arkansas

Decided to break up a trip from Chicago and stayed here. The price f the rooms was great. Beds and pillows were fantastic. All of the staff was fantastic. Themorning free breakfast was really good wit... more

Owner Response
Paul W, Owner at Best Western Plus Sikeston, responded to this review
Hello Valued Guest, We are happy to hear that you enjoyed your stay with us. Our staff works very to make sure each guest is comfortable from the time you arrive till the time you depart. Our breakfast is great with biscuits and gravy, waffles, scrambled eggs, and a variety of pastries. We appreciate you business and hope to see you again! Safe Travels!

nice hotel

12/01/2018 M2599DRpatriciam, Bastrop, Texas

I was extremely surprised to find such a nice hotel in that area. It is so much nicer than many I've stayed at. Very clean. Would have been great if I was staying longer, then I could have taken advan... more

Owner Response
Anita J, General Manager at Best Western Plus Sikeston, responded to this review
Hello, Wow that was an awesome review. We appreciate when guest take the time to review our hotel. We are located right off the interstate so some may think we are just a regular hotel but we are family oriented with great customer service. If ever in the area again, stop by and see us we appreciate your business! Every guest, Every Time!

Not as Nice As Expected/Desired

02/01/2018 jcisler, Grand Rapids MI

When traveling from Michigan to Texas and back, we have stayed at a few different hotels in Sikeston hoping to find a winner. This Best Western is not it. The beds are rock hard - too firm for me - ... more

Owner Response
Anita J, General Manager at Best Western Plus Sikeston, responded to this review
Valued Guest, I apologize that you felt that our hotel did not fit your expectations. Our breakfast does consist of waffles with a variety of toppings, biscuits and gravy, boiled eggs, sausage and scrambled eggs. Bagels and yogurt is also available. I am sorry that you did not sleep well but you need to know that our goal is to assist the guest to the best of our ability unfortunately you did not feel that way and hopefully you will give us another chance if ever in the area. We appreciated you business and hope to see you again!