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Best Western Plus Sikeston

AAA - 2 Diamond

Rooms & Rates

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Sikeston hotels are convenient and make traveling easy, and this popular favorite is located close to Interstate 55 and 57.

Your Best Western Plus Sikeston is pet-friendly, welcoming the entire family whether its for a vacation or business trip. Hotels in Sikeston are renowned for hospitality, but the bar is set high at this property. Near the Sikeston Rodeo, there are endless entertainment options that draw travelers from around the country. Business travelers and leisure travelers alike enjoy the homey amenities and great customer service.

Looking for the best Sikeston, MO hotels? Our property is affordable and boasts the absolute best service in town. A popular stopping point for travelers, make sure to visit some local favorites like Lamberts Caf, just a few minutes away from this Sikeston hotel. The Azalea Festival is a favorite local event, and theres always something special happening nearby. Ask a friendly staff member for recommendations or an insiders tip on must-see destinations.

Business travelers with Tyson Foods, Unilever and Noranda Aluminum depend on our Sikeston hotel for extended stays. Offering corporate travelers and government employees, such as those with BNSF, the best rates in town guarantees a stress-free trip. Newly renovated and just 20 miles to the Mississippi River, you deserve only the best Sikeston hotel on your next trip. Plus, staying 30 miles to the nearest casino means the best in gaming and entertainment is a short commute away.

Reserve your next stay at Best Western Plus Sikeston where the comfort of guests is a top priority! Enjoy your stay.

The pool is closed for repairs until April 21, 2017. We apologize for this inconvenience.

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120 S Interstate Drive
United States
AAA - 2 Diamond


Pets: No Pets accepted
Check-in & Check-out
15:00:00 | 11:00:00


Location and Attractions

Getting there.

Sat nav users: type 63801-8641

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120 S Interstate Drive
United States

What's nearby?


  • 13.00 mile(s) from Charleston

  • 53.00 mile(s) from Poplar Bluff

  • 55.00 mile(s) from Caruthersville

  • 60.00 mile(s) from Paducah, Kentucky

  • 60.00 mile(s) from Perryville

  • 65.00 mile(s) from Blytheville, Arkansas

  • 70.00 mile(s) from Metropolis, Illinois

  • 140 mile(s) from St. Louis

  • 150 mile(s) from Memphis, Tennessee

  • 13.00 mile(s) from Benton

  • 265 mile(s) from Branson

  • 20.00 mile(s) from New Madrid

  • 20.00 mile(s) from Dexter

  • 30.00 mile(s) from Cape Girardeau

  • 40.00 mile(s) from Jackson

  • 0.05 mile(s) from Steward Steel, 101 N. Interstate Drive, Sikeston, MO. 573-471-2121

  • 0.05 mile(s) from FedEx® Shipping Center, 2830 E Malone, Sikeston, MO.

  • 2.00 mile(s) from Tetra Pak®, 2200 E. Malone Avenue, Sikeston, MO. 573-471-1441

  • 4.00 mile(s) from Unilever® South Plant, 1000 County Line Road Sikeston, MO. 573-471-7051

  • 5.00 mile(s) from Cott Beverage, 301 Larcel Drive, Sikeston, MO 573-471-4445

  • 6.00 mile(s) from Atlas Cold Storage, 2500 Rose Parkway, Sikeston, MO 573-471-7727

  • 6.00 mile(s) from Americold® Logistics, 2500 Rose Parkway, Sikeston, MO. 573-471-7727

  • 6.00 mile(s) from Missouri Department of Transportation (MoDOT), 2675 N. Main Street, Sikeston, MO. 573-472-5333

  • 6.00 mile(s) from Do it Best, 2600 Rose Parkway, Sikeston, MO. 573-472-5770

  • 6.00 mile(s) from Unilever® North Plant, 2400 Rose Parkway, Sikeston, MO.

  • 6.00 mile(s) from Cargill®, 410 W. Malone Avenue, Sikeston, MO. 573-472-2272

  • 7.00 mile(s) from Orgill, 2727 N. Main Street, Sikeston, MO. 573-471-2071

  • 8.00 mile(s) from Alan Wire, 814 S. West Street, Sikeston, MO. 573-471-9548

  • 20.00 mile(s) from Tyson® Foods, 1001 E. Stoddard Street, Dexter, MO.

  • 26.00 mile(s) from Noranda® Aluminum, 391 Saint Jude Industrial Park, Marston, MO. 573-643-2361

  • 3 mile(s) from Three Rivers Community College

  • 8 mile(s) from Southeast Missouri State, four year university

Room Theatre Classroom U-Shape Boardroom Banquet
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Contact events on 0845 620 0506


TripAdvisor Traveller Rating: Rating: Based on 246 traveller reviews
Rating: 5 145
Rating: 4 69
Rating: 3 16
Rating: 2 11
Rating: 1 5

Don't believe the hype

26/04/2017 Katie B,

Room was not as clean as I would have expected from reviews. The man working the desk in the am was more interested in his morning gossip than being polite to guests. Would have been nice to start my ... more


Sleep, Glorious Sleep

15/04/2017 D S, Federal Way, Washington

Had a good nights sleep when needed after a long day's travel, and a late start. Although located near the freeway, there was no sound from it, and no sounds from outside the room to disturb our sleep... more

Owner Response
Audrey H, General Manager at BEST WESTERN PLUS Sikeston, responded to this review
Thank you so much for the review. We love to hear that our guests have a pleasant stay with us.

never again

08/04/2017 Parker T,

After checking in and given directions to my room, I couldn't help but notice a strange odor in the 1st floor hallway. Similar to cat urine. The room itself was odor free, but just appeared dark & o... more

Owner Response
Paul W, Manager at BEST WESTERN PLUS Sikeston, responded to this review
I am very sorry about your experience at our hotel. Everything seems to have been wrong with this experience. This is not what we like to see or hear about our hotel. These issues will be addresses with appropriate team members and solutions to make sure this wont happen again will be put in place. We were slacking apparently in areas we shouldn't have been. Thank you for making me aware of the changes that need to be made.

Passing through, super comfortable

05/04/2017 crace1089, Port Washington, Wisconsin

We stayed here after a long day home from Texas. The room was so nice I actually wish we could've spent more time here. It was a corner room, really spacious, HUGE bathroom. Very clean, liked the wate... more

Owner Response
Audrey H, General Manager at BEST WESTERN PLUS Sikeston, responded to this review
Thank you so much for the review. This makes our day and I will let the staff know they were given props for their idea of extra water in the rooms. Its nice to hear that their involvement in small things do matter and make an impression. Thanks so much!

Sikeston Mo stay

03/04/2017 Sally C, Beloit, United States

This is a BW plus so expected a little more, beds were good, room was good. However, we had 1 bar of soap and nothing else Note said complementary products available at front desk but when we checked ... more

Owner Response
Audrey H, General Manager at BEST WESTERN PLUS Sikeston, responded to this review
I am sorry to hear about the experience during your stay. Agree, that these items should have been provided and are now aware that we need to be more prepared in areas like this. Thank you for bringing this to our attention. I will use this as a learning tool for organization throughout our hotel.