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Sikeston hotels are convenient and make traveling easy, and this popular favorite is located close to Interstate 55 and 57.

Your BEST WESTERN PLUS Sikeston is pet-friendly, welcoming the entire family whether its for a vacation or business trip. Hotels in Sikeston are renowned for hospitality, but the bar is set high at this property. Near the Sikeston Rodeo, there are endless entertainment options that draw travelers from around the country. Business travelers and leisure travelers alike enjoy the homey amenities and great customer service.

Looking for the best Sikeston, MO hotels? Our property is affordable and boasts the absolute best service in town. A popular stopping point for travelers, make sure to visit some local favorites like Lamberts Caf, just a few minutes away from this Sikeston hotel. The Azalea Festival is a favorite local event, and theres always something special happening nearby. Ask a friendly staff member for recommendations or an insiders tip on must-see destinations.

Business travelers with Tyson Foods, Unilever and Noranda Aluminum depend on our Sikeston hotel for extended stays. Offering corporate travelers and government employees, such as those with BNSF, the best rates in town guarantees a stress-free trip. Newly renovated and just 20 miles to the Mississippi River, you deserve only the best Sikeston hotel on your next trip. Plus, staying 30 miles to the nearest casino means the best in gaming and entertainment is a short commute away.

Reserve your next stay at BEST WESTERN PLUS Sikeston where the comfort of guests is a top priority! Enjoy your stay.

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120 S Interstate Drive
United States
AAA - 2 Diamond


Pets: No Pets accepted
Check-in & Check-out
15:00:00 | 11:00:00
  • Low rate guarantee
  • Free WIFI
  • 270+ hotels in GB

Rooms & Rates


Location and Attractions

Getting there.

Sat nav users: type 63801-8641

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120 S Interstate Drive
United States

What's nearby?


  • 13.00 mile(s) from Charleston

  • 53.00 mile(s) from Poplar Bluff

  • 55.00 mile(s) from Caruthersville

  • 60.00 mile(s) from Paducah, Kentucky

  • 60.00 mile(s) from Perryville

  • 65.00 mile(s) from Blytheville, Arkansas

  • 70.00 mile(s) from Metropolis, Illinois

  • 140 mile(s) from St. Louis

  • 150 mile(s) from Memphis, Tennessee

  • 13.00 mile(s) from Benton

  • 265 mile(s) from Branson

  • 20.00 mile(s) from New Madrid

  • 20.00 mile(s) from Dexter

  • 30.00 mile(s) from Cape Girardeau

  • 40.00 mile(s) from Jackson

  • 0.05 mile(s) from Steward Steel, 101 N. Interstate Drive, Sikeston, MO. 573-471-2121

  • 0.05 mile(s) from FedEx® Shipping Center, 2830 E Malone, Sikeston, MO.

  • 2.00 mile(s) from Tetra Pak®, 2200 E. Malone Avenue, Sikeston, MO. 573-471-1441

  • 4.00 mile(s) from Unilever® South Plant, 1000 County Line Road Sikeston, MO. 573-471-7051

  • 5.00 mile(s) from Cott Beverage, 301 Larcel Drive, Sikeston, MO 573-471-4445

  • 6.00 mile(s) from Atlas Cold Storage, 2500 Rose Parkway, Sikeston, MO 573-471-7727

  • 6.00 mile(s) from Americold® Logistics, 2500 Rose Parkway, Sikeston, MO. 573-471-7727

  • 6.00 mile(s) from Missouri Department of Transportation (MoDOT), 2675 N. Main Street, Sikeston, MO. 573-472-5333

  • 6.00 mile(s) from Do it Best, 2600 Rose Parkway, Sikeston, MO. 573-472-5770

  • 6.00 mile(s) from Unilever® North Plant, 2400 Rose Parkway, Sikeston, MO.

  • 6.00 mile(s) from Cargill®, 410 W. Malone Avenue, Sikeston, MO. 573-472-2272

  • 7.00 mile(s) from Orgill, 2727 N. Main Street, Sikeston, MO. 573-471-2071

  • 8.00 mile(s) from Alan Wire, 814 S. West Street, Sikeston, MO. 573-471-9548

  • 20.00 mile(s) from Tyson® Foods, 1001 E. Stoddard Street, Dexter, MO.

  • 26.00 mile(s) from Noranda® Aluminum, 391 Saint Jude Industrial Park, Marston, MO. 573-643-2361

  • 3 mile(s) from Three Rivers Community College

  • 8 mile(s) from Southeast Missouri State, four year university

Room Theatre Classroom U-Shape Boardroom Banquet
Have an enquiry?
Contact events on 0845 620 0506


  • TripAdvisor
TripAdvisor Traveller Rating: Rating: Based on 216 traveller reviews
Rating: 5 135
Rating: 4 57
Rating: 3 12
Rating: 2 8
Rating: 1 4

Yearly vacation to husband's birthplace.

18/10/2016 Nancy S,

We really liked the location and amenities of this hotel. The management staff was very friendly and helpful. We had requested a first floor room and our request was honored. We have stayed at this... more


Best Sikeston Western Mo not Less

16/10/2016 Royce V, Bowling Green

Excellent stay. Comfortable beds. Very clean room. Efficient and courteous staff who helped us locate on internet church for the next morning. Bathrooms clean and efficiently laid out. Just a good... more


Best West

07/10/2016 Kay M, Pensacola, Florida

This by far is the friendliest Best Western we have every stayed. They cannot do enough to make you stay comfortable and are very accommodating to making your stay enjoyable. We stay here often and l... more


A Beautiful little hotel that offered a LOT!

11/09/2016 Yolonda N, Raymore, United States

This hotel was very clean and up-to-date inside and out. It was very small but fully-loaded with amenities: indoor pool, microwave, refrigerator, access to computers, free breakfast, free wifi, fitnes... more


Friendly staff, Filthy carpet, Room reaked of smoke

08/09/2016 Dawn R,

The website says that this hotel has been renovated. They may have renovated the rooms , but the carpets in the hallway are absolutely filthy. The first room we were put in room 124 absolutely reeked ... more