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Welcome to BEST WESTERN On the River!


We are one block up from historic downtown Hannibal and two blocks up from the Mississippi River. The hotel is within walking distance of the Mark Twain boyhood home, museum and riverboat, plus many different bars and restaurants. Bars and restaurants within walking distance include LaBinnah Bistro, The Brick Oven, Mark Twain Brewing Company, Big Muddy BBQ, Java Jive, Christian Ambiance Caf, Becky Thatchers Diner, Mark Twain Dinette, Rumor Has It, Ole Planters Restaurant, Finns Food and Spirits, and La Azotea Cocktail Lounge.

Downtown also offers a variety of specialty shoppes such as antiques, boutiques, beauty salons, an art gallery, a gelato shop and book stores. There is also a local B7B Theater that opened in 2009. Along with the movie theater Bluff City opened in 2015 and puts on a variety of plays throughout the year. Hannibal has a minor league baseball team called the Cavemen and they host games during the summer at Clemens Field, which is less than a mile from the Best Western On the River. We are also only two miles away from popular tourist attractions like Mark Twain Cave and family fun park Sawyers Creek.

The Best Western On the Rivers main building includes an indoor pool and hot tub, exercise room, free high speed fiber internet, river view rooms and a free hot breakfast that includes: eggs, sausage, biscuits and gravy, and a waffle makes. Thirty additional rooms have been added to the Best Western On the River as well. The new building opened in 2015 and is right next door from the main building. All rooms on the second and third floor of the new building have river views. and twenty-four of the thirty rooms offer TWO King beds. The new building also has fiber internet (wired and wireless), its own free hot breakfast, exercise room and guest laundry area. Come Stay with us, and enjoy the attractions Americas Hometown has to offer!

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401 N 3rd Street
United States
AAA - 3 Diamond


Pets: No Pets accepted
Check-in & Check-out
15:00:00 | 11:00:00
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Rooms & Rates


Location and Attractions

Getting there.

Sat nav users: type 63401-3301

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401 N 3rd Street
United States

What's nearby?


  • 20 mile(s) from Quincy, IL

  • 70 mile(s) from Nauvoo, IL

  • 98 mile(s) from Columbia

  • 100 mile(s) from St Louis

  • 100 mile(s) from Springfield, IL

  • 106 mile(s) from Jefferson City

  • 108 mile(s) from Burlington, IA

  • 147 mile(s) from Lake of the Ozark

  • 295 mile(s) from Branson

  • 300 mile(s) from Chicago, IL

  • 300 mile(s) from Indianapolis, IN

  • 383 mile(s) from Louisville, KY

  • 461 mile(s) from Nashville, TN

  • 477 mile(s) from Little Rock, AR

  • 512 mile(s) from Green Bay, WI

  • 641 mile(s) from Minneapolis, MN

  • 670 mile(s) from Atlanta, GA

  • 679 mile(s) from Dallas, TX

  • 864 mile(s) from Houston, TX

  • 4.00 mile(s) from Continental Cement Company

  • 4.00 mile(s) from Altorfer Inc..

  • 5.00 mile(s) from Buckhorn Industries, rubber products

  • 5.00 mile(s) from Watlow Industries

  • 5.00 mile(s) from General Mills

  • 5.00 mile(s) from Hannibal Clinic

  • 5.00 mile(s) from James E. Cary Cancer Center

  • 5.00 mile(s) from Hannibal Regional Hospital

  • 9.00 mile(s) from BASF Corporation, Hannibal site

  • 20.00 mile(s) from Pace Industries Leggett & Platt Aluminum Group

  • 2 mile(s) from Hannibal-LaGrange College

  • 3 mile(s) from Moberly Area Community College, Hannibal campus

  • 20 mile(s) from Quincy University

  • 20 mile(s) from John Wood Community College

  • 20 mile(s) from Vatterott College

  • 20 mile(s) from Blessing Rieman College of Nursing

  • 30 mile(s) from Culver-Stockton College

  • 70 mile(s) from Moberly Area Community College, Moberly campus

  • 80 mile(s) from Westminster College

  • 100 mile(s) from University of Missouri

Room Theatre Classroom U-Shape Boardroom Banquet
Have an enquiry?
Contact events on 0845 620 0506


  • TripAdvisor
TripAdvisor Traveller Rating: Rating: Based on 626 traveller reviews
Rating: 5 318
Rating: 4 223
Rating: 3 56
Rating: 2 13
Rating: 1 16

Nice Hotel

25/10/2016 101Holidayer, Mesa, Arizona

We stayed overnight here on our trip down the Great River Road. I booked it online. It was very easy to find. Signs pointed directly to it. At checkin I asked if we had a room with a River view and t... more


"Still Hannibal's Best!" donna d. Las Vegas,NV.

25/10/2016 donna d, Las Vegas, Nevada

Are you kidding me? Where do I start? My room looked South and East on the quiet end of the third floor,so I got to view the Lord's sunrise and sunset overlooking the Mississippi River every day! I c... more


Great Location In Hannibal.

25/10/2016 Scott B, Huntertown

Very nice hotel. Rooms have just been updated. Breakfast bar is pretty good. The location is perfect. We walked to almost every thing in Hannibal (shops, restaurants, mansion tour) We were there ... more


Enjoyable stay in Hannibal, Mo

25/10/2016 Richard N, Modesto, United States

Hannibal is a fascinating place to visit. I was able to stay only one day and a night but would love to go back and when I do I will stay again at the Best Western On the River for it certainly is. I ... more


Not worth the stay

25/10/2016 Megan P,

I came to Hannibal on a business trip and after reading several reviews I decided this hotel would probably be the best one in the area. There were two front desk receptionists when I checked in, one... more