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Welcome to the BEST WESTERN Hotel JTB/Southpoint!

Sand and surf are minutes away from this Jacksonville hotel, centrally located on one of the main freeways to the beaches.

Guests looking for the ultimate tropical getaway in paradise can have it all. At St. John Town Center, enjoy world class dining and shopping. A centralized location to Jacksonville businesses and amenities means the best of the city is at your fingertips, such as the FSCJ Artist Series featuring Broadway Musicals, shows and concerts from some of todays biggest pop and country singers.

Hotels near the Mayo Clinic Jacksonville offer easy commutes for medical tourists, too. Our proximity to the Mayo Clinic, Proton Center and other medical-oriented businesses like PSS World Medical simplify trips for those who are visiting loved ones or in town for appointments. With the ability to host larger groups due to the number of rooms with two beds, families traveling together, whether for medical appointments or special events like reunions, can make the most of the trip.

Enjoy the closest Best Western property to the city center. Actively participating in several marathons such as the National Breast Cancer Marathon and Gate River Run, staff members work closely with amateur athletic associations, and this Jacksonville hotel is proudly the host property for the Jacksonville Sharks Arena Football Team. Stay close to the World Golf Hall of Fame and home of the NFLs Jacksonville Jaguars.

From sports teams to corporate travelers, hotels near downtown are designed to make guests comfortable. When traveling for business with CSX Transportation or in town for an event at the Prime Osborne Convention Center, the complimentary breakfast, outdoor swimming pool, fitness center, sauna and high speed Internet access make you feel at home. Service men and women with the U.S. Navy visiting Naval Base Mayport, and academics who need hotels near the University of North Florida enjoy our competitive rates. Enjoy your stay.

Guests must be 21 years of age or older with government issued ID to check in. We thank you for selecting our hotel. Were in the process of refreshing our product for you, our loyal guests. Thank you for your understanding.

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4660 Salisbury Road
United States


Pets: No Pets accepted
Check-in & Check-out
16:00:00 | 11:00:00
  • Low rate guarantee
  • Free WIFI
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Rooms & Rates


Location and Attractions

Getting there.

Sat nav users: type 32256-6130

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4660 Salisbury Road
United States

What's nearby?


  • 8.00 mile(s) from Orange Park

  • 10.00 mile(s) from Jacksonville Beach

  • 15.00 mile(s) from Ponte Vedra Beach

  • 35.00 mile(s) from Fernandina Beach

  • 40.00 mile(s) from St. Augustine

  • 40.00 mile(s) from Amelia Island

  • 45.00 mile(s) from Kings Bay, GA

  • 45.00 mile(s) from St. Mary's, GA

  • 75.00 mile(s) from Daytona Beach

  • 160 mile(s) from Orlando

  • 0.30 mile(s) from St. Lukes Hospital - Jacksonville

  • 1.00 mile(s) from CSX Transportation

  • 2.00 mile(s) from TNT/Logistics

  • 4.00 mile(s) from Mayo Clinic - Jacksonville

  • 8.00 mile(s) from Prime Osborne Convention Center

  • 4.00 mile(s) from University of North Florida

  • 10.00 mile(s) from Jacksonville University

Cities & Attractions

  • 10.00 mile(s) from Jacksonville Beach

Room Theatre Classroom U-Shape Boardroom Banquet
Have an enquiry?
Contact events on 0845 620 0506


  • TripAdvisor
TripAdvisor Traveller Rating: Rating: Based on 770 traveller reviews
Rating: 5 318
Rating: 4 187
Rating: 3 128
Rating: 2 74
Rating: 1 63

Great room and excellent value

04/12/2016 rodsee63, Pekin, Indiana

Would stay there again! Appreciate the great and caring service. The breakfast was very good like Best Western Hotels usually are. I would recommend this Hotel to friends and family when staying in Ja... more


Best Western JTB Southpoint

02/12/2016 cynthiat583, Summerville, South Carolina

Decent room but lacked basic amenities like refrigerator and microwave. Had other issues also. This hotel was going thru transition to another chain but had several issues such as breakfast problems a... more


Rockville 2015 & 2016

26/11/2016 WannaBfoodie, Port Orange, Florida

We've stayed here for the past two years for Rockville a two day rock festival held at metropolitan park. This hotel is about a 15min drive with quick and easy access from I-95, free parking, comforta... more


Not worth 100$ a night

20/11/2016 skywitt1234, Lake City, Florida

My husband and I Decided to go to Jacksonville for my birthday. The room had no refrigerator and also smelt like dog piss, The phone was broken. None of the vending machines worked. They charged doubl... more


Great Ending After a Long Day of Travel

16/11/2016 dskeetbuster, Sharpsville, Pennsylvania

When we arrived at the hotel, handicap parking was available and convenient for unloading and loading. The reservations were as expected with the plus of receiving an end room on a quiet floor. The ... more