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Welcome to the BEST WESTERN Hotel JTB/Southpoint!

Sand and surf are minutes away from this Jacksonville hotel, centrally located on one of the main freeways to the beaches.

Guests looking for the ultimate tropical getaway in paradise can have it all. At St. John Town Center, enjoy world class dining and shopping. A centralized location to Jacksonville businesses and amenities means the best of the city is at your fingertips, such as the FSCJ Artist Series featuring Broadway Musicals, shows and concerts from some of todays biggest pop and country singers.

Hotels near the Mayo Clinic Jacksonville offer easy commutes for medical tourists, too. Our proximity to the Mayo Clinic, Proton Center and other medical-oriented businesses like PSS World Medical simplify trips for those who are visiting loved ones or in town for appointments. With the ability to host larger groups due to the number of rooms with two beds, families traveling together, whether for medical appointments or special events like reunions, can make the most of the trip.

Enjoy the closest Best Western property to the city center. Actively participating in several marathons such as the National Breast Cancer Marathon and Gate River Run, staff members work closely with amateur athletic associations, and this Jacksonville hotel is proudly the host property for the Jacksonville Sharks Arena Football Team. Stay close to the World Golf Hall of Fame and home of the NFLs Jacksonville Jaguars.

From sports teams to corporate travelers, hotels near downtown are designed to make guests comfortable. When traveling for business with CSX Transportation or in town for an event at the Prime Osborne Convention Center, the complimentary breakfast, outdoor swimming pool, fitness center, sauna and high speed Internet access make you feel at home. Service men and women with the U.S. Navy visiting Naval Base Mayport, and academics who need hotels near the University of North Florida enjoy our competitive rates. Enjoy your stay.

Guests must be 21 years of age or older with government issued ID to check in. We thank you for selecting our hotel. Were in the process of refreshing our product for you, our loyal guests. Thank you for your understanding.

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4660 Salisbury Road
United States


Pets: No Pets accepted
Check-in & Check-out
16:00:00 | 11:00:00
  • Low rate guarantee
  • Free WIFI
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Rooms & Rates


Location and Attractions

Getting there.

Sat nav users: type 32256-6130

Send to Tom Tom

4660 Salisbury Road
United States

What's nearby?


  • 8.00 mile(s) from Orange Park

  • 10.00 mile(s) from Jacksonville Beach

  • 15.00 mile(s) from Ponte Vedra Beach

  • 35.00 mile(s) from Fernandina Beach

  • 40.00 mile(s) from St. Augustine

  • 40.00 mile(s) from Amelia Island

  • 45.00 mile(s) from Kings Bay, GA

  • 45.00 mile(s) from St. Mary's, GA

  • 75.00 mile(s) from Daytona Beach

  • 160 mile(s) from Orlando

  • 0.30 mile(s) from St. Lukes Hospital - Jacksonville

  • 1.00 mile(s) from CSX Transportation

  • 2.00 mile(s) from TNT/Logistics

  • 4.00 mile(s) from Mayo Clinic - Jacksonville

  • 8.00 mile(s) from Prime Osborne Convention Center

  • 4.00 mile(s) from University of North Florida

  • 10.00 mile(s) from Jacksonville University

Cities & Attractions

  • 10.00 mile(s) from Jacksonville Beach

Room Theatre Classroom U-Shape Boardroom Banquet
Have an enquiry?
Contact events on 0845 620 0506


  • TripAdvisor
TripAdvisor Traveller Rating: Rating: Based on 743 traveller reviews
Rating: 5 307
Rating: 4 183
Rating: 3 123
Rating: 2 69
Rating: 1 61

pet friendly

28/09/2016 Lyzze, Weeki Wachee, Florida

The hotel staff was friendly to us and accepted our pet without hesitation. The room was typical hotel room but didn't have a refrigerator for my pet's food for the 2 night we stayed thus I had to was... more


dirty & poor service

25/09/2016 Bev M, Jasper, Florida

PLEASE don't stay here this hotel is very nasty and rude employees, we worked midnight and stayed here I asked for clean towels in the morning b/c the maids don't start cleaning till 10am the manager ... more



18/09/2016 dgjgsg, Tampa, Florida

Excellent location to downtown, bay-meadows business area, next to major highway , short distance to shopping and beaches - main reason is trusted staff - I had left a bag filled with valuable items- ... more


Best hotel for youe money

13/09/2016 Mary H, Tampa, Florida

We stayed at this hotel during our visit to the Mayo clinic. Hotel is very clean and a nice free breakfast. Wish we could have stayed longer to enjoy the pool and weight room. Will definitely return o... more


Nice Hotel

04/09/2016 Martin B, Nashville, United States

This was a nice place to stay. Their breakfast needs a lot of improvement but otherwise everything was great. Only 20 minutes from the beach and much less expensive than the hotels on the beach. The ... more